Changes of soluble triggering receptor expressed on myeloid cells-1 and lactate in children with purulent meningitis
10.3760/cma.j.issn.2095-428X.2013.11.019
- VernacularTitle:可溶性髓样细胞触发受体1、乳酸在细菌性脑膜炎患儿中的变化
- Author:
Zhi-Hong ZHUO
1
;
Guo GUO
;
Pei-Chao TIAN
;
Qiang LUO
;
Huai-Li WANG
Author Information
1. 450052,郑州大学第一附属医院儿科
- Keywords:
Purulent Meningitis;
Viral meningitis;
Soluble triggering receptor expressed on myeloid cells-1;
Lactate;
Diagnose;
Differential diagnosis
- From:
Chinese Journal of Applied Clinical Pediatrics
2013;28(11):864-867
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the diagnosis significance of soluble triggering receptor expressed on myeloid cells-1 (STREM-1) and lactate in children with purulent meningitis,and to investigate the changes of STREM-1,lactate in cerebrospinal fluid(CSF) of purulent meningitis before and after treatment.Methods Dry chemical method and enzyme linked immunosorbent assay(ELISA) were used to measure STREM-1 and lactate levels in CSF of purulent meningitis group (24 cases),viral meningitis group (27 cases),CSF normal group (25 cases) and purulent meningitis after treatment group(22 cases).Results 1.STREM-1 and lactate levels in CSF were higher in patients with purulent meningitis than in those with viral meningitis and CSF normal group(all P ＜ 0.05).2.STREM-1 and lactate levels in CSF were higher in patients with purulent meningitis before treatment than those after treatment(all P ＜ 0.05).3.The area under the curve(AUC) of STREM-1 in CSF was 0.891,and at a cutoff level of 27.86 ng/L STREM-1 yielded a sensitivity of 80.8％ and specificity of 75.0％ ;the AUC of CSF lactate was 0.940,and at a cutoff level of 1.75 mmol/ L lactate yielded a sensitivity of 90.4％ and specificity of 83.3％.Conclusions 1.STREM-1 and lactate were associated with bacterial infection,they have considerable diagnostic values in purulent meningitis.2.STREM-1 and lactate maybe worthless in differential diagnosis of purulent meningitis when treated by effective antibiotics.3.The decline of STREM-1 and lactate in CSF prompts the control of infection and good prognosis.
