Analysis about risk factors of autism disorder in 278 children
10.3760/cma.j.issn.2095-428X.2013.11.018
- VernacularTitle:儿童孤独症278例发病危险因素研究
- Author:
Yi-Qun HE
1
;
Guang-Lei XUN
;
Xiao-Yan MA
;
Jing-Ping ZHAO
Author Information
1. 新乡医学院第二附属医院临床心身一科
- Keywords:
Autism;
Risk factors;
Child
- From:
Chinese Journal of Applied Clinical Pediatrics
2013;28(11):860-863
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the high risk factors of the etiology of autism disorder.Methods Two hundred and seventy-eight children with autism disorder and 200 healthy children were investigated with self-designed questionnaire to obtain their demographic information,pre-and perinatal information,developmental information in toddler period.All the data were compared between autism group and healthy controls.Results 1.There were significant dif ferences in maternal prenatal data and perinatal data between autism group and healthy controls.Logistic regression analysis found that maternal/paternal reproductive age,family burden,caregiver,pregnancy reaction,drug administration in prenatal period,mode of delivery,chief instructor entered the regression equation.2.The 6 items in regression equation which had clinical significance consisted of maternal reproductive age above 30 years old [odds ratio (OR) =6.72],family history of mental disorders (OR =5.80),drug administration in prenatal period (OR =4.65),non-natural childbirth (OR =4.15),paternal reproductive age above 30 years old (OR =1.27),moderate or serious pregnancy reaction (OR =1.04).Conclusions The main risk factors of autism disorder in pre-and perinatal period consists of maternal reproductive age above 30 years old,positive family history of mental disorders,drug administration in prenatal period and non-natural childbirth.Avoiding these risk factors might contribute to reduce the incidence of autism.
