Correlation of the serum hydrogen sulfide level and neuron-specific enolase level in children with febrile seizures
10.3760/cma.j.issn.2095-428X.2013.10.019
- VernacularTitle:热性惊厥患儿血清硫化氢水平测定及其与血清神经元特异性烯醇化酶的相关性
- Author:
Hong LI
1
;
Ju-Hua ZHOU
;
Wei SHEN
;
Su-Zhen FANG
;
Jiang DU
;
Qi-Yi ZENG
Author Information
1. 南方医科大学珠江医院儿科中心
- Keywords:
Hydrogen sulfide;
Febrile seizures;
Neuron specific enolase;
Brain damage
- From:
Chinese Journal of Applied Clinical Pediatrics
2013;28(10):786-789
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the pathophysiological role of serum hydrogen sulfide (H2 S) and its correlation with serum neuron-specific enolase (NSE) level in the process of febrile seizures (FS).Methods Sixty-five children with FS and acute upper respiratory infection were selected as FS group,51 children with acute upper respiratory infection associated with fever were taken as upper respiratory infection group and 43 healthy children in Child Health Section for physical examination were respectively chosen as the healthy control group.All children came from Department of Pediatrics of Zhujiang Hospital,Southern Medical University from Mar.15 to Nov.10,2012.The serum H2S and NSE levels of all groups were measured by Microplate Reader.Results The serum H2S in FS group was significantly lower than that in upper respiratory infection group and healthy control group (all P ＜ 0.01) ; the NSE level in FS group was significantly higher than that in upper respiratory infection group and healthy control group (all P ＜0.01) ;the levels of H2S and NSE had no significant differences between upper respiratory infection group and healthy control group (all P ＞ 0.05).The serum H2S level and NSE level in FS group were negatively correlated (r =-0.279,P =0.024) ; There were significant differences of serum NSE level between seizure frequency less than twice group and seizure frequency greater than or equal to twice group(t =-2.955,P =0.004).The seizure frequency was negatively correlated with serum H2S level (r =-0.269,P =0.03),and positively correlated with serum NSE level (r =0.322,P =0.009).The seizure durations (≥ 5 min) was negatively correlated with serum H2S level (r =-0.532,P =0.019).Conclusion The serum H2S level is expected to be an objective index for eva-luating the seizure brain injury in the early period of FS,and also potentially the important occurrence factors of brain injury.
