Application of tetrahydrobiopterin in treatment of phenylketonuria
10.3760/cma.j.issn.2095-428X.2013.08.021
- VernacularTitle:四氢生物蝶呤在苯丙酮尿症治疗中的应用
- Author:
Zi-Chuan FAN
1
;
Wen-Hao ZHOU
Author Information
1. 复旦大学附属儿科医院新生儿科
- Keywords:
Tetrahydrobiopterin;
Phenylalanine hydroxylase;
Phenylketonuria
- From:
Chinese Journal of Applied Clinical Pediatrics
2013;28(8):632-634
- CountryChina
- Language:Chinese
-
Abstract:
Until recently,the common treatment for phenylketonuria (PKU) was a phenylalanine (Phe)-restricted diet.Increasing evidence of suboptimal outcomes was observed in diet-treated individuals.The observation of clinically significant reductions in blood Phe levels in a subset of patients with PKU following oral administration of tetrahydrobiopterin(BH4),a cofactor of phenylalanine hydroxylase.Clinical studies suggest that treatment with BH4 provides better Phe control and increases dietary Phe tolerance,allowing significant relaxation or even discontinuation of dietary Phe restriction.The current knowledge on this novel pharmacologic approach to the treatment of PKU will be discussed.
