Relationship between bilirubin/albumin ratio, auditory brainstem responses and bilirubin-induced neurotoxicity
10.3760/cma.j.issn.2095-428X.2013.08.018
- VernacularTitle:胆红素/清蛋白比值及脑干听觉诱发电位与胆红素神经毒性的相关性
- Author:
Dan WANG
1
;
Bo YANG
;
Rui-Ping ZHENG
Author Information
1. 山东大学附属省立医院新生儿科
- Keywords:
Hyperbilirubinemia;
Bilirubin/albumin;
Auditory brainstem response;
Newborn infant
- From:
Chinese Journal of Applied Clinical Pediatrics
2013;28(8):621-623
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between serum total bilirubin (TBIL),total bilirubin/albumin ratio (B/A ratio) and bilirubin-induced neurotoxicity,and to analyze the sensitivity of brainstem function and auditory nerval function in auditory brainstem responses (ABRs) in full-term newborn infants with hyperbilirubinemia.Methods Ninety-one cases of full-term neonates with hyperbilirubinemia were divided into 4 groups according to the findings of ABRs:group A(with normal ABRs),group B (only brainstem dysfunction),group C (only auditory neural damage),group D(brainstem dysfunction and auditory nerval damage).TBIL,B/A ratio were compared among these groups and the relationships were analyzed between TBIL,B/A ratio and ABRs.Results Between group A and group B,there was no significant difference in TBIL(t =1.566,P ＞ 0.05),but there was a significant difference in B/A ratio (t =1.898,P ＜ 0.05),the TBIL and B/A ratio in group C were significantly higher than those in group B (tTBIL =2.372,PTBIL ＜ 0.05 ;tB/A =2.794,PB/A ＜ 0.01).Between group A and group C,group A and group D,group B and group D,the TBIL had significant differences(t =2.452,3.328,2.256,all P ＜ 0.05) ; Between group A and group C,group A and group D,group B and group D,the B/A ratio had significant differences(t =2.571,4.680,2.657,all P ＜0.05,0.01);there were no significant difference in TBIL and B/A ratio between group C and group D(tTBIL =0.705,PTBIL ＞ 0.05 ; tB/A =0.636,PB/A ＞ 0.05).The ROC of the TBIL and B/A ratio were 0.919,0.829,TBIL and B/A ratio were well correlated with ABRs(r =0.495,0.564,all P ＜ 0.05).Conclusions The B/A ratio is a good indicator for bilirubin-induced neurotoxicity in full-term infants.Brainstem function is more subjected than auditory nerve damage in ABR dysfunction.
