Research progress of microRNA in mitochondrial dysfunction of children with sepsis
10.3760/j.issn.2095-428X.2013.06.017
- VernacularTitle:microRNA在脓毒症患儿线粒体功能障碍的研究进展
- Author:
Di CHE
1
;
Yuan-Bin SONG
;
Yang WANG
;
Zhi-Jiang CHEN
;
Piao-Hong LIANG
;
Qi-Yi ZENG
Author Information
1. 南方医科大学珠江医院儿科中心
- Keywords:
microRNA;
Sepsis;
Mitochondria dysfunction;
Oxidant stress;
Inflammatory response
- From:
Chinese Journal of Applied Clinical Pediatrics
2013;28(6):459-461
- CountryChina
- Language:Chinese
-
Abstract:
Sepsis is the systemic inflammatory respond syndrome and autoimmunity injury caused by pathogenic microorganism or any other immunogenicity.Mitochondria,an important organelle,which has an essential role in cellular growth,metabolism,occurrence and development of disease by generating ATP following the oxidative phosphorylation from glycolysis.There had been some progresses on the research of sepsis in several decades.A number of studies had shown that the degree of mitochondrial dysfunction was related to the eventual outcome of sepsis.microRNA are endogenous small noncoding RNAs that post-transcriptionally regulate gene and bio-protein expression,and then adjust mitochondrial oxidative stress,has important influence on the process of sepsis and prognosis.Here,a current review of how microRNA impinge on mitochondrial dysfunction in sepsis was performed.
