Serum levels of macrophage migration inhibitory factor, tumor necrosis factor-α and interleukin-6 in children with mycoplasma pneumoniae pneumonia and their significances
10.3760/cma.j.issn.2095-428X.2013.04.017
- VernacularTitle:肺炎支原体肺炎患儿血清巨噬细胞移动抑制因子、肿瘤坏死因子-α、白细胞介素-6表达的意义
- Author:
Zhi-Yong LI
1
;
Chun-Fang HAN
Author Information
1. 261041,潍坊市人民医院小儿内科
- Keywords:
Mycoplasma pneumoniae pneumonia;
Macrophage migration inhibitory factor;
Tumor necrosis factor-α;
Interleukin-6
- From:
Chinese Journal of Applied Clinical Pediatrics
2013;28(4):291-293
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the serum levels oi macrophage migration inhibitory factor (MIF),tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in children with mycoplasma pneumoniae pneumonia (MPP) and their clinical significance.Methods The serum levels of MIF,TNF-α and IL-6 were detected by enzyme-linked immuno sorbent assay in 42 children with acute MPP (acute MPP group),26 children with recovery MPP (recovery MPP group),25 children with bacterial pneumonia (bacterial pneumonia group),and 30 normal healthy children (healthy control group).Correlations between MIF and TNF-α as well as IL-6 were analyzed in MPP group.Results The serum levels of MIF,TNF-α and IL-6 in acute MPP group were significantly higher than those of recovery MPP group,bacterial pneumonia group and healthy control group (all P ＜ 0.01,0.05),whereas there was no significant difference between recovery MPP group and healthy control group (P ＞ 0.05).Serum levels of MIF,TNF-α and IL-6 in bacterial pneumonia group were significantly increased compared with those in healthy control group (all P ＜ 0.05).There were positive correlations between MIF and TNF-α as well as IL-6 in acute MPP (r =0.76,0.82,all P ＜ 0.05),whereas there was no correlation between MIF and TNF-α as well as IL-6 in recovery MPP(r =0.26,0.31,all P ＞ 0.05).Conclusions MIF,TNF-α and IL-6 may play significant roles in the pathogenesis of MPP,and combined detection of the three factors has great referential value in assessing the severity and predicting the prognosis for MPP.
