Investigation of platelet membrane glycoprotein Ibα gene polymorphisms in children with Kawasaki disease

VernacularTitle:川崎病患儿血小板膜糖蛋白Ibα基因多态性分析
Author: Zhuo-Ying LI ¹ ; Lin HUANG ; Zuo-Cheng YANG
Author Information

1. 中南大学湘雅三医院儿科
Keywords: Platelet glycoprotein Ibα; Kawasaki disease; Gene polymorphism
From: Chinese Journal of Applied Clinical Pediatrics 2013;28(3):220-222
CountryChina
Language:Chinese
Abstract: Objective To investigate the association between platelet glycoprotein Ibα (GPIbα) gene HPA-2a/b polymorphisms and the risk of Kawasaki disease (KD) and that complicated with coronary artery lesion (CAL).Methods A total of 30 patients with KD and 60 healthy controls were genotyped by polymerase chain reaction-restriction fragment length polymorphism and agarose gel electrophoresis for the HPA-2a/b polymorphism in GPIbα gene.Results For HPA-2a/b polymorphism in GPIbα gene,there was only genotype TC and CC of HPA-2a/b polymorphism in GPIbα gene in children with KD and healthy controls,and genotype TF was not found in both groups.There were no significant differences between KD patients and the controls in genotype frequencies of CC,TC and TT and allele frequencies of C and T (x2 =0.052,0.048,all P ＞ 0.05) ; also there was no significant difference between KD patients with CAL and that without CAL in genotype and allele frequencies (x2 =2.672,2.481,all P ＞ 0.05).Conclusion No association is found between HPA-2a/b polymorphism in GPIbα gene and the risk of KD or its complication of CAL in this study.