Expression of platelet membrane glycoproteins in pediatric idiopathic thrombocytopenic purpura and its clinical significance
10.3760/cma.j.issn.2095-428X.2013.03.015
- VernacularTitle:特发性血小板减少性紫癜患儿血小板膜糖蛋白表达及临床意义
- Author:
Na WANG
1
;
Yi-Huan CHAI
;
Hai-Long HE
;
Jian-Qin LI
;
Lan CAO
;
Li-Juan CAO
Author Information
1. 215003,苏州大学附属儿童医院血液/肿瘤科
- Keywords:
Idiopathic thrombocytopenic purpura;
Platelet membrane glycoprotein;
Efficacy;
Child
- From:
Chinese Journal of Applied Clinical Pediatrics
2013;28(3):210-213
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between the expression of platelet membrane glycoprotein in pediatric idiopathic thrombocytopenic purpura (ITP) and its clinical significance.Methods A modified monoclonal antibody immobilization of platelet antigen (MAIPA) method was used to detect the positive expression rates of 4 platelet membrane glycoproteins (GP Ⅰ b/Ⅸ,GP Ⅰ b,GP Ⅲ a,and GP Ⅰ b) in 80 pediatric patients with ITP.The correlation was explored between the GP positive rate and the clinical efficacy in pediatric ITP.Trying to observe the correlationship between the GP positive rate of pediatric ITP in the total,the different gender,the acute and chronic and the treatment response rate in pediatric ITP respectively.Results There was a significant difference in curative rate statistically between the GP positive group and the GP negative group(x2 =8.535,P ＜ 0.01) in 80 pediatric ITP patients,but no statistic difference in curative rate existed between the 36 female and 44 male(x2 =0.013,P ＞0.05).Markedly statistic difference was found in the female(x2 =4.433,P ＜ 0.05),the same to the male (x2 =4.156,P ＜ 0.05).Meanwhile,there was an extremely statistic difference between 67 acute and 13 chronic patients(x2 =23.513,P ＜ 0.001).Apparently statistic difference also occurred in the acute (x2 =4.157,P ＜ 0.05),but not in the chronic cases (x2 =0.410,P ＞ 0.05).Conclusions The clinical response rate is significantly correlated with the GP positive rate in pediatric ITP,but not correlated with gender.The GP positive rate can reflect the disease status of pediatric ITP to a certain extent and be used as an indicator for judging the efficacy and monitor prognosis of pediatric ITP.
