Risk factors and complications of severe meconium aspiration syndrome in neonates
10.3760/cma.j.issn.2095-428X.2013.02.004
- VernacularTitle:重症胎粪吸入综合征新生儿危险因素及并发症
- Author:
Yi FENG
1
;
Tao XIONG
;
Yi QU
;
Jin-Lin WU
;
De-Zhi MU
Author Information
1. 四川大学华西第二医院儿科
- Keywords:
Meconium aspiration syndrome;
Risk factor;
Complication;
Infant,newborn
- From:
Chinese Journal of Applied Clinical Pediatrics
2013;28(2):89-91
- CountryChina
- Language:Chinese
-
Abstract:
Objective To provide the clinical evidence for early diagnosis of meconium aspiration syndrome (MAS) and to prevent its complications.Methods One hundred and seven cases of neonates diagnosed with MAS treated in Department of Neonatology,West China Second Hospital,Sichuan University,from Dec.2006 to Dec.2011were analyzed retrospectively.They were assigned into severe MAS group (52 cases) and non-severe MAS group (55 cases) according to whether need mechanical ventilation(including positive end-expiratory pressure and invasive ventilation).Comparisons were carried out with SPSS 15.0,including the general situation of the newborns,obstetric characteristics and complications of both groups.Results There were significant differences in 1 min,5 min and 10 min Apgar score,intrauterine distress,endotracheal intubation meconium suction between the 2 groups.The common complications of MAS were hypoxic-ischemic encephalopathy (HIE) (61.7％),myocardium injury (43.0％),metabolism disorder (41.1％) and intracranial hemorrhage (20.6％).The incidences of HIE,metabolism disorder,disseminated intravascular coagulation,intracranial hemorrhage,pulmonary hemorrhage,myocardium injury and kidney injury in severe MAS group were significantly higher than those in non-severe MAS group.However,no in crease of the prevalence of severe MAS was proved because of clinical conditions,such as maternal pregnancy complications and cesarean section.Conclusions Intrauterine distress and asphyxia are associated with increased the risk of severe MAS.MAS,especially severe one,can lead to multiple organ dysfunction,so it deserves much closer caring and monitoring.
