Coexistence of systemic sclerosis and ankylosing spondylitis:A case report and literature review

VernacularTitle:系统性硬化症合并强直性脊柱炎1例及文献复习
Author: Shulin HU ¹ ; Xiaoxia ZUO ; Yisha LI
Author Information

1. 中南大学湘雅医院风湿免疫科
Keywords: systemic sclerosis; ankylosing spondylitis; creatine kinase
From: Journal of Central South University(Medical Sciences) 2018;43(11):1263-1265
CountryChina
Language:Chinese
Abstract: Systemic sclerosis (SSc) is an autoimmune disease characterized by thickening of the skin and organ fibrosis.Ankylosing spondylitis (AS) is a type of arthritis with long-term inflammation of the axial joints.Previous studies presented 5 cases of concomitant AS and SSc.However,there was only 1 patient of those 5 cases complaining of muscle weakness while all patients had approximately normal creatine kinase (CK).Here we reported a young male who met the criteria for SSc and AS while showing significantly elevated CK.Human leukocyte antigen (HLA) typing results indicated the genetic susceptibility to these two diseases.The patient was prescribed prednisone (30 mg/d)and cydophosphamide.After 2 months,the patient's skin became soft with normal CK.