Optimized the preparation process of thermo-sensitive Yinhuang ophthalimic gel by central composite design-response surface method
10.3760/cma.j.issn.1673-4246.2019.01.016
- VernacularTitle:星点设计-效应面优化眼用银黄温敏凝胶的制备工艺
- Author:
Zhi CHEN
1
;
Siyong YE
Author Information
1. 山东中医药大学药学院
- Keywords:
Gels (TCD);
Central composite design-response surface method;
Poloxamer;
Dosage forms improving
- From:
International Journal of Traditional Chinese Medicine
2019;41(1):67-71
- CountryChina
- Language:Chinese
-
Abstract:
Objective To optimize the preparation technology of thermo-reversible Yinhuang opthalimic gel by the central composite design-response surface method.Methods The poloxamer 407 and poloxamer 188 were used as the investigation factors, and the evaluation index was the gel temperature. Central composite design-response surface method was used to evaluate the mathematic relation between the evaluation index and tow investigation indexes to identify the optimum prescription.Results According to the quadratic models, it was found that there was reliable quantitative relation between the evaluation index and two investigation indexes,among which the optimun dosage was 20％ for P407, 1％ for P188, 0.1％ for hyaluronic acid, 0.01％ for benzalkonium chloride, 0.02％ for EDTA.Conclusions This method is reliable and feasible, whicn can realize the prescription optimization of the gel.
