Analysis of the disease free survival and prognostic factors of patients with stage Ⅲa non small cell lung cancer with traditional Chinese medicine intervention after radical operation
10.3760/cma.j.issn.1673-4246.2019.01.003
- VernacularTitle:中医药干预Ⅲa期非小细胞肺癌根治术后无病生存期及预后相关因素分析
- Author:
Deqi KONG
1
;
Lingshuang LIU
;
Yi JIANG
;
Liping SHEN
Author Information
1. 上海中医药大学附属龙华医院肿瘤六科 200032
- Keywords:
Traditional Chinese medicine intervention;
Ⅲa non small cell lung cancer;
Radical operation;
Disease-free survival;
Prognosis;
Protective factors;
Factor analysis,statistical
- From:
International Journal of Traditional Chinese Medicine
2019;41(1):8-13
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the factors influencing the disease-free survival (DFS) and prognosis of patients with non small cell lung cancer after Ⅲa stage resection, and to evaluate the effect of traditional Chinese medicine intervention.Methods A total of 148 cases met the inclusion criteria were enrolled in the study. The DFS, 1-, 2- and 3-year disease-free survival rates were analyzed. Univariate and multivariate survival analysis were used to investigate the prognostic factors.Results In the analysis of 148 cases, the DFS was 17.49 months, 1 years, 2 years, 3 years disease-free survival rates were 62％, 40％, 29％. Single factor analysis showed that the duration of DFS was 21.03 months, and the difference was statistically significant (P<0.001) for 8.26 months without the intervention of Chinese medicine (TCM). Open chest surgery, syndrome differentiation, oral medicine, oral medicine dialectical decoction continuous time, vein used traditional Chinese medicine preparation course, traditional Chinese medicine to the route of administration, multidisciplinary intervention methods for prognosis related factors(P<0.05). Multivariate analysis showed that vein used traditional Chinese medicine preparation course (≥4 courses) and traditional Chinese medicine intervention (≥six months time), syndrome differentiation, oral administration of traditional Chinese medicine combined with intravenous preparations continued administration were the non-independent protective factors for disease-free survival and prognosis (P<0.05). Postoperative application of intravenous formulation more than or equal to four courses showed 57.1％ risks of recurrence and metastasis than the those fewer than 4 courses. After operation is Postoperative continued intervention of traditional Chinese medicine more than or equal to 6 months showed 50.4％ risks of recurrence and metastasis than the those fewer than 6 months. Postoperative adminstration of intravenous and oral traditional Chinese medicine showed 27.7％ risks of recurrence and metastasis than the those fewer than only TCM syndromes differentiation of traditional Chinese medicine.Conclusions The combination of syndrome differentiation with oral and intravenous application of traditional Chinese medicine helps to delay the recurrence and metastasis of postoperative stage Ⅲa NSCLC.
