Single Clone of Toxic Shock Syndrome Toxin 1-Producing Methicillin-Resistant Staphylococcus Aureus Isolated from a Neonatal Intensive Care Unit Patients.
- Author:
Won Keun SONG
1
;
Chang Hee OH
;
Seung Joo KIM
;
Tae Jae LEE
;
Min Jeong PARK
;
Dong Hoon SHIN
;
Sung Ha KANG
;
Kyu Man LEE
Author Information
1. Department of Clinical Pathology, Hallym University College of Medicine, Seoul, Korea. swonkeun@hallym.or.kr
- Publication Type:Original Article
- Keywords:
Toxic shock syndrome toxin-1;
Methicillin-resistant Staphylococcus aureus;
Neonatal intensive care unit;
Repetitive-element PCR
- MeSH:
Clone Cells*;
Humans;
Infant, Newborn;
Intensive Care, Neonatal*;
Methicillin Resistance*;
Methicillin-Resistant Staphylococcus aureus*;
Polymerase Chain Reaction;
Shock, Septic*;
Staphylococcus aureus
- From:Korean Journal of Clinical Microbiology
2002;5(1):21-25
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Six babies infected with Staphylococcus aureus occurred in a neonatal intensive care unit (NICU) over a period of 2 months, which was successfully controlled with the aid of moleculartyping of the isolates. METHODS: We examined the staphylococcal toxins, mecA and tst gene PCR, and repetitive-element PCR (rep-PCR) typing in S. aureus isolated from the clinical specimens of infected babies, nasal swabs of the patients and medical personnels in a NICU, and environmental equipments. RESULTS: Among all S. aureus isolates tested, they were toxic shock syndrome toxin 1 (TSST-1)- producing methicillin-resistant S. aureus (MRSA) who have mecA and tst gene, and one identical rep- PCR pattern all, except 3 MRSA isolated from the nasal swabs of 2 non-infected patients and 1 medical personnel. CONCLUSIONS: It was demonstrated that TSST-1 producing MRSA became epidemic in the NICU as a result of the spread of a single clone.
