Clinical study of Yangsheng-Yishen decoction combined with irbesartan in the treatment of early diabetic nephropathy
10.3760/cma.j.issn.1673-4246.2018.11.008
- VernacularTitle:养生益肾汤联合厄贝沙坦治疗早期糖尿病肾病临床研究
- Author:
Juan LYU
1
;
Rui ZHANG
;
Lanxiu CAO
;
Fu BAI
Author Information
1. 陕西中医药大学中药教研室
- Keywords:
Diabetic nephropathies;
Yangsheng-Yishen decoction;
Irbesartan;
Comparative effectiveness research
- From:
International Journal of Traditional Chinese Medicine
2018;40(11):1033-1036
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy of Yangsheng-Yishen decoction combined with irbesartan in the treatment of early diabetic nephropathy (DN).Methods A total of 95 patients with early DN who met the inclusion criteria were randomly divided into control group (47 cases) and treatment group (48 cases).The control group was treated with irbesartan,while the treatment group was given Yangsheng-Yishen decoction on the basis of the control group.The two groups were treated for 6 months.The FBG,HbAlc,urinary albumin excretion rate (UAER),Scr,TG,TC,LDL-C and HDL-C were detected by automatic biochemical analyzer.The level of vascular endothelial growth factor (VEGF),platelet derived growth factor (PDGF),tumor necrosis TNF-α and transforming growth TGF-β were measured by elisa assay,and the clinical efficacy was evaluated.Results After treatment,the levels of FBG,HbAlc,UAER and SCr in the treatment group was significantly lower than those in the control group (t=3.886,4.056,9.346,8.806,all P＜0.01).After treatment,the serum TG,TC and LDL-C of the treatment group were significantly lower than those of the control group (t=8.294,12.800,6.153,all P＜0.001),and HDL-C was significantly higher than that of the control group (t=4.293,P＜0.01).The levels of serum VEGF,PDGF,TNF-α and TGF-β in the treatment group was significantly lower than those in the control group (t=13.585,11.613,10.774,10.490 respectively,all P＜0.01).Conclusions The Yangsheng-Yishen decoction combined with irbesartan can reduce blood sugar,blood lipid and urinary protein level in early DN patients,improve renal function.
