A study on the effect of Qingjin-Huazhuo prescription on the FeNO in the patients with phlegm heat accumulation of lung syndrome in acute exacerbation of chronic obstructive pulmonary disease
10.3760/cma.j.issn.1673-4246.2018.11.006
- VernacularTitle:清金化浊方对慢性阻塞性肺疾病急性加重期痰热蕴肺证患者呼出气一氧化氮的影响
- Author:
Wei WU
1
;
Bin WANG
;
Wei WANG
;
Huimei LIU
;
Shan LI
;
Feng GAO
Author Information
1. 中国中医科学院望京医院呼吸科
- Keywords:
Pulmonary disease,chronic obstructive;
Qingjin-Huazhuo prescription;
Phlegm heat accumulation of lung syndrome;
Fractional exhaled nitric oxide
- From:
International Journal of Traditional Chinese Medicine
2018;40(11):1025-1028
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of the Qingjin-Huazhuo prescription on the fractional exhaled nitric oxide (FeNO) in the patients with phlegm heat accumulation of lung syndrome in acute exacerbation of chronic obstructive pulmonary disease (AECOPD).Methods A total of 72 patients with phlegm heat accumulation of lung syndrome in AECOPD who met the criteria were included were randomly divided into two groups,36 in each group.The control group received the conventional western medicine treatment,and the observation group received the additional Qingjin-Huazhuo prescription on the basis of the western medicine treatment.The duration of treatment was 10 days.The changes of TCM syndromes,FeNO and pulmonary function (FEV 1％,FVC％,FEV 1/FVC) on both two groups before and after treatment were recorded and compared.Results The improvement of cough,phlegm,wheeze and total score of TCM syndrome in the observation group were significantly better than the control group (t=3.091,2.303,3.063,2.412,P＜0.05).The improvement of FeNO in the observation group was significantly better than the control group (9.81 ± 12.10 ppb vs.3.42 ± 14.78 ppb,t=2.007) (P＜0.05).As for the pulmonary function,the improvement of FEV1％,FVC％,FEV1/FVC in the observation group were better than the control group (t=1.295,1.187,0.829,P=-0.200,0.240,0.411),but the differences were not significantly.Conclusions The Qingjin-Huazhuo prescription on the basis of conventional western medicine treatment for patientswith phlegm heat accumulation of lung syndrome in AECOPD,showed the improvement of symptoms,inhibit the inflammation in the respiratory tract and improve the ventilation function.
