Study on cell matrix of pancreatic duct adenocarcinoma
10.3760/cma.j.issn.1673-422X.2018.11.013
- VernacularTitle:胰腺导管腺癌细胞基质研究
- Author:
Rongchun XING
1
;
Zhouping QIN
Author Information
1. 三峡大学第一临床医学院急诊与创伤外科
- Keywords:
Carcinoma,pancreatic ductal;
Signal transduction;
Extracellular matrix;
Tumor microenvironment
- From:
Journal of International Oncology
2018;45(11):696-698
- CountryChina
- Language:Chinese
-
Abstract:
The occurrence of pancreatic duct adenocarcinoma (PDAC) is closely related to the biological immunological characteristics of the hematopoietic matrix of its cancer cells.The malignant characteristics of the cancer matrix play important roles in the malignant origin of tumors,avoiding immune surveillance,promoting tumor progression and growth,and increasing drug resistance and metastasis.Understanding the important roles of hyaluronic acid,Sonic Hedgehog signaling pathway,transforming growth factor-beta,CD40,Kras pathway and microRNA in the pathogenesis and development of PDAC,can provide new strategies for clinical treatment of PDAC.
