Mechanisms of tumor-derived exosomes promoting tumor metastasis

VernacularTitle:肿瘤细胞来源的外泌体在肿瘤转移中的作用及其机制
Author: Yi WANG ¹ ; Xiaosan SU
Author Information

1. 650011,昆明医科大学附属甘美医院(昆明市第一人民医院)生物医学实验中心
Keywords: Neoplasm metastasis; Neovascularization,pathologic; Tumor-derived exosomes; Epithelial mesenchymal transition
From: Journal of International Oncology 2018;45(11):681-684
CountryChina
Language:Chinese
Abstract: Exosomes are microvesicles ranging from approximately 40-150 nm in size,which mediate the exchange of information between cells by releasing proteins,nucleic acids,etc.Tumor-derived exosomes (TEXs) may facilitate tumor metastasis through various mechanisms such as forming the premetastatic niche in the terminal organs,they can regulate immune cells and immune-related molecules in the tumor microenvironment to promote tumor immune escape,they can also induce tumor angiogenesis and increase vascular permeability,promoting the epithelial-mesenchymal transformation of tumor cells,etc.Understanding the mechanism of TEXs in tumor metastasis can provide new ideas for effective prevention and treatment of tumor metastasis.