Research progress on zinc finger protein GLi in development and treatment of hepatocellular carcinoma
10.3760/cma.j.issn.1673-4203.2019.02.013
- VernacularTitle:锌指蛋白GLi在肝细胞癌的发生、发展及治疗中的研究进展
- Author:
Huiqi ZHAO
1
;
Baolong DONG
;
Xiaohua DONG
;
Xiaojun YANG
Author Information
1. 甘肃中医药大学
- Keywords:
Carcinoma,hepatocellular;
Biology;
Signal transduction;
Zinc finger protein GLi
- From:
International Journal of Surgery
2019;46(2):127-131
- CountryChina
- Language:Chinese
-
Abstract:
Hepatocellular carcinoma is one of the most common malignant tumors in the world,and its morbidity and mortality have been high.The current preferred treatment for hepatocellular carcinoma is surgical treatment and liver transplantation,but the 5-year survival rate is still low.Due to the insidious onset of hepatocellular carcinoma,most patients have no special manifestations at the initial stage.At the time of diagnosis,they are already in the terminal stage and lose the opportunity of surgery.The Hh pathway plays a key role in the development of tumors.The zinc finger protein GLi plays an important role in tumorigenesis as a key transcription factor in the Hh pathway.At the same time,zinc finger protein GLi can play a key role in the invasion and metastasis of hepatocellular carcinoma by inducing epithelial-mesenchymal transition.In addition,the zinc finger protein GLi also interacts with various tumor-related factors to affect the occurrence and development and treatment of hepatocellular carcinoma.This article reviews the role of zinc finger protein GLi in the development and treatment of hepatocellular carcinoma.
