Research progress of miR-224 in colorectal cancer
10.3760/cma.j.issn.1673-4203.2018.12.015
- VernacularTitle:MiR-224在结直肠癌中的研究进展
- Author:
Meiyuan YANG
1
;
Daorong WANG
Author Information
1. 中南大学湘雅二医院普外科
- Keywords:
Target gene repair;
Colorectal neoplasms;
Review;
MiR-224
- From:
International Journal of Surgery
2018;45(12):850-854
- CountryChina
- Language:Chinese
-
Abstract:
Colorectal cancer is the third most common cancer in humans and poses a serious threat to human health.MicroRNAs (miRNAs) affected the mechanism of occurrence and development of colorectal cancer.As an important member of miRNA,miR-224 modulates the migration,proliferation,metastases and drug resistance of colorectal cancer by acting on its downstream targets.The expression of miR-224 affects the prognosis of colorectal cancer.Therefore,this review summarizes the role of miR-224 and its downstream targets in colorectal cancer,it may provide a new method for diagnosis and treatment to colorectal cancer at the cellular and molecular level.
