Axonal injury and repair mechanism after ischemic stroke
10.3760/cma.j.issn.1673-4165.2018.10.010
- VernacularTitle:缺血性卒中后轴突损伤与修复机制
- Author:
Changsheng WANG
1
;
Dongli SUN
Author Information
1. 100094,解放军第二六一医院急诊科
- Keywords:
Stroke;
Brain Ischemia;
Neurons;
Axons;
Nerve Degeneration
- From:
International Journal of Cerebrovascular Diseases
2018;26(10):774-779
- CountryChina
- Language:Chinese
-
Abstract:
The process of axonal injury after ischemic stroke can be roughly divided into three stages. Each stage has its different temporal and spatial pattern, as well as unique molecular cascade reactions. The process of axonal injury is also related to ischemic stroke subtype, and the treatment must be adjusted accordingly. Axon-glial intercellular neurotransmitter-energy metabolism coupling disorder and Ca2 + overload-mediated apoptosis-like degeneration are the main mechanisms of early axonal injury after stroke. Axonal regeneration and remyelination of damaged axons after stroke play an important role for the recovery of neurological function. Elucidating the axonal injury and repair mechanism after stroke can provide a new strategy for stroke treatment.
