Early repetitive pain in preterm infants in relation to brain development
10.3760/cma.j.issn.1673-4408.2019.01.005
- VernacularTitle:早期反复疼痛刺激与早产儿脑发育的关系
- Author:
Junjie XU
1
;
Jiao YIN
;
Rui CHENG
Author Information
1. 南京医科大学附属儿童医院新生儿医疗中心 210008
- Keywords:
Preterm infants;
Repeated pain stimulation;
Brain development;
Analgesia
- From:
International Journal of Pediatrics
2019;46(1):19-22
- CountryChina
- Language:Chinese
-
Abstract:
With the improvement of medical care the survival rate of preterm infants (gestational age ＜ 37 weeks) increased dramatically,however long-term neurodevelopmental and behavioral problems are still a concern.During their stay in neonatal intensive care unit preterm patients suffer lots of repeated painful procedures while it's a period of rapid brain development.Preterm infants have the nociceptive circuitry to feel the pain,but this system is functionally immature.Because the spinal neuromodulation system is immature that repeated pain stimulation leads to increased nociceptive signaling in the central nervous system.Besides,specific cell populations in the central nervous system of preterm infants are particularly vulnerable to oxidative stress and inflammation.Therefore,it is important that pain-related stress in preterm infants is appropriately managed.
