Progress on vaccination of children with hemophilia A
10.3760/cma.j.issn.1673-4408.2019.01.002
- VernacularTitle:血友病A患儿的疫苗接种研究进展
- Author:
Yuefang WU
1
;
Zhuo LI
;
Juan XIAO
Author Information
1. 中国医学科学院北京协和医院儿科
- Keywords:
Hemophilia A;
Vaccination;
Inhibitors
- From:
International Journal of Pediatrics
2019;46(1):5-9
- CountryChina
- Language:Chinese
-
Abstract:
Hemophilia A is a hereditary hemorrhagic disease.Vaccination can prevent certain diseases,while intramuscular vaccination may lead to muscle hematoma in children with hemophilia A,even become a high risk factor for increasing production of inhibitors.Therefor,there are concerns about vaccination of hemophilia A.Children with hemophilia A can be vaccinated in a relatively safe manner,such as subcutaneous injections,or vaccinated after replacement treatment.There is no clear correlation between the immune response induced by vaccination and the mechanism of inhibitor production,and the safety of vaccination remains to be further studied.This review focuses on the progress of vaccination for children with hemophilia A.
