Research progress of intestinal flora imbalance in children with nonalcoholic fatty liver disease
10.3760/cma.j.issn.1673-4408.2018.12.012
- VernacularTitle:肠道菌群失调在儿童非酒精性脂肪肝中的研究进展
- Author:
Zhenni ZHU
1
Author Information
1. 湖北省妇幼保健院儿童消化科
- Keywords:
Children;
Nonalcoholic fatty liver disease;
Intestinal flora
- From:
International Journal of Pediatrics
2018;45(12):948-951
- CountryChina
- Language:Chinese
-
Abstract:
Nonalcoholic fatty liver disease (NAFLD) has become the most common chronic liver disease in children.Compared with adults,NAFLD in children progresses rapidly and the prognosis is poor.A number of studies have demonstrated that intestinal flora imbalance plays an important role in the pathogenesis of NAFLD.The development of microbes in the intestinal can be traced back to the intrauterine period,and the diversity of microbes mainly occurs in childhood.At present,the exploration of drug therapy for children with NAFLD is still underway.Adjusting the intestinal flora can improve the state of oxidative stress and inflammatory injury in the liver,so as to improve the body's metabolic abnormality and delay the progression of liver disease in NAFLD patients,which has important clinical significance in preventing and treating NAFLD in children.
