Progress of B lymphocyte activating factor/a proliferation inducing ligand in Henoch-Schonlein purpura nephritis
10.3760/cma.j.issn.1673-4408.2018.12.008
- VernacularTitle:B细胞活化因子/增殖诱导配体与紫癜性肾炎的研究进展
- Author:
Wanhong ZHU
1
Author Information
1. 中国医科大学附属盛京医院小儿肾脏风湿免疫科
- Keywords:
Henoch-schonlein purpura nephritis;
B lymphocyte activating factor;
A proliferation inducing ligand
- From:
International Journal of Pediatrics
2018;45(12):933-937
- CountryChina
- Language:Chinese
-
Abstract:
Henoch-schonlein purpura nephritis(HSPN) is the most common secondary glomerular disease in children.The pathogenesis of HSPN is unclear.In recent years,there have been some reports on B lymphocyte activating factor(BAFF) and a proliferation inducing ligand (APRIL),new members of the tumor necrosis factor family,as well as their association with HSPN.This paper reviews the related research from the following aspects:structure and biological functions of BAFF and APRIL,the role of BAFF/APRIL in the pathogenesis of HSPN,the prospect of BAFF and APRIL targeted biological agents in the treatment of HSPN.It provides a reference for further research on BAFF/APRIL system and HSPN.
