The genes research progress in frontal lobe epilepsy
10.3760/cma.j.issn.1673-4408.2018.12.007
- VernacularTitle:额叶癫痫相关基因的研究进展
- Author:
Mingyue LENG
1
Author Information
1. 400014,重庆市渝中区 重庆医科大学附属儿童医院神经内科
- Keywords:
Frontal lobe epilepsy;
Gene;
Treatment
- From:
International Journal of Pediatrics
2018;45(12):929-932
- CountryChina
- Language:Chinese
-
Abstract:
Frontal lobe epilepsy,of which the morbidity is second to temporal lobe epilepsy,is one of the most common types of focal epilepsy.Its clinical manifestations are diversiform.Ictal electroencephalogram (EEG) and cranial imaging examinations are helpful in diagnosis making,but the misdiagnosis rate is still high.With the development of gene diagnosis and precision medicine in recent years,the use of genetic tests is increasing for frontal lobe epilepsy.Autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) as a common type of frontal lobe epilepsy is most closely associated with gene mutations.So far,6 kinds of genetic mutations have been found associating with frontal lobe epilepsy.Research progress in pathogenic mutafons will enhance the advancement of diagnosis and treatment of frontal lobe epilepsy.
