The role of mitochondria in the pathogenesis of bronchial asthma
10.3760/cma.j.issn.1673-4408.2018.12.006
- VernacularTitle:线粒体在哮喘发病机制中的作用
- Author:
Zhijia WANG
1
Author Information
1. 中国医科大学附属盛京医院小儿呼吸内科
- Keywords:
Asthma;
Mitochondria;
Pathogenesis
- From:
International Journal of Pediatrics
2018;45(12):924-928
- CountryChina
- Language:Chinese
-
Abstract:
Bronchial asthma is a heterogeneous disease characterized by chronic airway inflammation,and its pathogenesis is complex.Epithelial mitochondrial damage is one of the important pathogenesis of asthma and an important bridge between airway inflammation and airway remodeling.Inhibition of mitochondrial damage,and thus inhibition of oxidative stress,may be an effective method to reduce epithelial cell damage and inhibit airway remodeling,which may be a breakthrough in asthma treatment.This review summarizes the role of mitoehondria in the pathogenesis of asthma.
