Immunomodulatory mechanism of long non-coding RNA and its research progress in bronchial asthma
10.3760/cma.j.issn.1673-4408.2018.12.003
- VernacularTitle:长链非编码RNA的免疫调节机制及其在支气管哮喘中的研究进展
- Author:
Bing DAI
1
Author Information
1. 中国医科大学附属盛京医院小儿呼吸科
- Keywords:
Long non-coding RNA;
Innate immunity;
Adaptive immunity;
Asthma
- From:
International Journal of Pediatrics
2018;45(12):911-915
- CountryChina
- Language:Chinese
-
Abstract:
Long non-coding RNA plays an important regulatory role in life activities of organisms and is widely involved in the pathological and physiological processes of organisms.Abnormal expression of long noncoding RNA also frequently occurrs in some inflammatory diseases.In these diseases,there may be excessive inflammatory damage,or an imbalance in the immune response.Bronchial asthma is a typical airway inflammatory disease,and the imbalance of immune response plays an essential role in its development.Long non-coding RNA may be involved in the regulation of the pathogenesis of asthma through the dual mechanism of innate and adaptive immunity.This review summarizes the immune-inflammatory regulation mechanism of long non-coding RNA and its preliminary research progresses in asthma.
