Treatment progress of elderly patients with acute promyelocytic leukemia
10.3760/cma.j.issn.1009-9921.2019.01.017
- VernacularTitle:老年人急性早幼粒细胞白血病治疗进展
- Author:
Tingting JIN
1
;
Renzhi PEI
Author Information
1. 宁波大学医学院附属鄞州医院血液科 315040
- Keywords:
Leukemia,promyelocytic,acute;
Elderly;
Treatment
- From:
Journal of Leukemia & Lymphoma
2019;28(1):60-64
- CountryChina
- Language:Chinese
-
Abstract:
Acute promyelocytic leukemia (APL) is a special subtype of acute myeloid leukemia characterized by an increase of abnormal promyelocytic cells, failure of bone marrow hematopoietic function accompanied by the chromosome translocation t (15;17). APL has become one of the best paradigms of successful molecule targeted therapy with the development of treatments; however, the overall survival (OS) of elderly APL patients was not optimistic. The discovery of all-trans retinoic acid, arsenic and new drugs has provided new therapeutic choices for elderly patients with APL. This article reviews the treatment progress of elderly patients with APL.
