Neuromyopathy caused by long term colchicine therapy
- Author:
Hyung Jun PARK
1
;
Hyung-Soo LEE
;
Heasoo KOO
;
Soo Jeong HAN
;
Euno CHOI
;
Chan Young LEE
;
Seung Ah LEE
;
Young-Chul CHOI
;
Kee Duk PARK
Author Information
1. Department of Neurology, Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung, Republic of Korea
- Publication Type:Case report
- Keywords:
colchicine;
toxicity;
muscular disease;
polyneuropathies
- From:Neurology Asia
2018;23(2):185-188
- CountryMalaysia
- Language:English
-
Abstract:
Colchicine-induced neuromyopathy is an extremely rare complication, and can develop in the setting of acute overdose or chronic administration in therapeutic doses. A 72-year-old man presented with proximal muscle weakness and myalgia. He had angina pectoris and Behçet’s disease, leading to the treatment of colchicine (1.2 mg daily for about 6 years), cyclosporine, methylprednisolone, simvastatin, and aspirin. A biceps brachii muscle biopsy was performed and electron microscopic examination revealed scattered autophagic vacuoles. He was initially treated with steroid pulse therapy. However, muscle weakness did not improve. After the discontinuation of colchicine, muscle power and myalgia improved steadily. There should be heightened awareness of colchicine-induced neuromyopathy because that clinical suspicion is the most important diagnostic clue, and termination of colchicine is the only treatment.
