Interleukin-28 Polymorphism: Ethnic variations and the response to chronic hepatitis C treatment in Malaysia
- Author:
Chee-Hoong HOE
1
;
Mohd Azri Mohd Suan
;
Chee-Hock HOE
;
Thean-Hock TANG
;
Kuang-Kiat KIEW
;
Muhammad Radzi Abu Hassan
;
Huan-Keat CHAN
Author Information
1. Medical Department, Hospital Sultanah Bahiyah, Alor Setar, Kedah, Malaysia.
- Publication Type:Journal Article
- Keywords:
chronic hepatitis C
- From:
The Medical Journal of Malaysia
2018;73(4):260-260
- CountryMalaysia
- Language:English
-
Abstract:
comprehensive overview of chronic hepatitis C (CHC)management.1 The author highlighted the concern over theexorbitant cost of direct-acting antivirals, which is the reason for their limited use in Malaysia currently. Based on the findings of the previous studies, the author also underlined that Asians receiving the conventional, interferon-based treatment generally have a higher sustained virological response (SVR) rate as compared with Caucasians and African Americans, mainly due to the interleukin-28B (IL28) single nucleotide polymorphism (SNP) across different ethnic populations. Nonetheless, to date, information on the variations in IL-28 genotypes among different ethnic groups in Malaysia is still limited.
- Full text:6.2018my1322.pdf
