Dapsone Hypersensitivity Syndrome and Dapsone-induced Liver Injury in Four Malaysian Indigenous Individuals with Leprosy
- Author:
Rajalingam RAMALINGAM
1
;
Chun Lai TOO
;
Min Moon TANG
Author Information
1. Department of Dermatology, Hospital Tengku Ampuan Afzan, Kuantan, Pahang, Malaysia
- Publication Type:Case Report
- Keywords:
Leprosy;
Dapsone;
Severe cutaneous adverse reaction;
HLA-B*13:01;
Malaysia
- From:Malaysian Journal of Dermatology
2018;40(June):73-79
- CountryMalaysia
- Language:English
-
Abstract:
Dapsone is part of the multi-drug therapy used in the treatment of leprosy. It can cause life-threateninghypersensitivity syndromes resulting in significant morbidity and mortality, especially amongsusceptible individuals such as those who are carriers of HLA-B*13:01 allele. Avoidance of dapsonein these susceptible individuals reduces the risk of dapsone-related adverse events. Herein, we reportfour indigenous patients with leprosy who developed dapsone hypersensitivity syndrome.
