Cutaneous Adverse Drug Reactions in Sabah: A 3-year study between 2014 - 2016
- Author:
Teck Sheng GAN
1
;
Yin Man LIM
;
Yui Ping TAN
;
Sivaraj A/L RAMAN
;
Melinda Kwan See Kee
;
Asmah JOHAR
Author Information
1. Department of Medicine, Hospital Tawau, Tawau, Sabah, Malaysia
- Publication Type:Original Article
- Keywords:
Cutaneous adverse drug reactions (CADRs);
Maculopapular rash;
Urticaria
- From:Malaysian Journal of Dermatology
2018;40(June):36-40
- CountryMalaysia
- Language:English
-
Abstract:
Introduction:Cutaneous adverse drug reactions are one of the most common adverse drug reactions. Publicationson clinical correlation between cutaneous presentations and causative agents are limited among thelocal population. This study aims to determine the clinical presentations of cutaneous adverse drugreactions and the causative drugs in the local population.Methods:A retrospective, cross sectional study was conducted from the pharmacy cutaneous adverse drugreaction database from January 2014 to December 2016 in Tawau, Keningau & Queen Elizabeth (KotaKinabalu) Hospitals.Results:A total of 859 cases of cutaneous adverse drug reactions were identified. Out of these, 53.3% (n=458)were females and 46.7% (n=401) were males. The mean age was 36 years old. Majority of patients were20-29 years old (16.6%) followed by 50-59 years old (15.1%). Most of the cases were reported amongthe Chinese community (16.4%), followed by the Malay (15.9%), Dusun (14.7%) and Bajau (14.0%)populations. The most common cutaneous manifestations were urticaria and or angioedema (49%, n=421) and maculopapular rash (39.6%, n=340). Severe cutaneous adverse reactions (SCAR) constituted2.8% in total. The major causative agent was antibiotic which accounted for 55.1% (n=473), followedby nonsteroidal anti-inflammatory drugs (NSAIDs), 28.1% (n=241) and analgesics, 10.8% (n=93).Conclusion:The types of cutaneous manifestations and causative drugs in Sabah are similar to those reported inother states of the country and abroad. This study provides evidence of local cutaneous adverse drugreaction characteristics in different ethnic group.
