Related factors of lymph node metastasis in lung adenocarcinoma patients with T1 stage
10.7507/1007-4848.201710016
- VernacularTitle:T1 期肺腺癌患者淋巴结转移相关因素分析
- Author:
YIN Chuntong
1
;
ZHANG Chunyan
1
;
LI Huawei
2
;
ZHANG Han
1
;
GUO Congying
1
;
ZHANG Linyou
1
Author Information
1. Department of Thoracic Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, P.R.China
2. Department of Thoracic Surgery, The First Affiliated Hospital of Xinxiang Medical University, Xinxiang, 453000, Henan, P.R.China
- Publication Type:Journal Article
- Keywords:
Ground glass nodules;
lung adenocarcinoma;
lymph node metastasis;
consolidation tumor ratio
- From:
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
2018;25(9):755-761
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between clinical features and lymph node metastasis in lung adenocarcinoma patients with T1 stage. Methods We retrospectively analyzed the clinical data of 253 T1-stage lung adenocarcinoma patients (92 males and 161 females at an average age of 59.45±9.36 years), who received lobectomy and systemic lymph node dissection in the Second Affiliated Hospital of Harbin Medical University from October 2013 to February 2016. Results Lymph node metastasis was negative in 182 patients (71.9%) and positive in 71 (28.1%). Poor differentiation (OR=6.988, P=0.001), moderate differentiation (OR=3.589, P=0.008), micropapillary type (OR=24.000, P<0.001), solid type (OR=5.080, P=0.048), pleural invasion (OR=2.347, P=0.024), age≤53.5 years (OR=2.594, P=0.020) were independent risk factors for lymph node metastasis. In addition, in the tumor with diameter≥1.55 cm (OR=0.615, P=0.183), although the cut-off value of 1.55 cm had no significant difference, it still suggested that tumor diameter was an important risk factor of lymph node metastasis. Conclusion In lung adenocarcinoma with T1 stage, the large tumor diameter, the low degree of differentiation, the high ratio of consolidation, and the micropapillary or solid pathological subtypes are more prone to have lymph node metastasis.
