Relationship between Platelet-specific Alloantibody and Gravidity or Recurrent Spontaneous Abortion
10.16753/j.cnki.1008-2344.2016.06.008
- VernacularTitle:血小板血型抗体与妊娠次数及复发性流产关系的研究
- Author:
Jie TANG
1
;
Yingying ZHAO
;
Wei WEI
;
Suwen YAN
;
Ning ZHANG
Author Information
1. 中国人民解放军第202医院优生优育研究所
- Keywords:
platelet-specific alloantibody;
recurrent spontaneous abortion;
solid-phase red cell adherence assay;
prenatal screen
- From:
Journal of Shenyang Medical College
2016;18(6):445-446,450
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the expression of platelet-specific alloantibody in the sera of primipara,pluripara,and recurrent spontaneous abortion (RSA) patients,and analyze the relationship between platelet-specific alloantibody and gravidity or RSA. Methods:A total of 100 primipara, 100 pluripara (gravidity≥2) and 100 RSA patients who received prenatal examination in department of aristogenesis, No. 202 Hospital of PLA from Apr 2015 to Dec 2015 were recruited. The blood samples were collected during 16-28 weeks of pregnancy, and the expression of platelet-specific alloantibody was detected by solid-phase red cell adherence assay. Results:There were 5 positive platelet-specific alloantibody in primipara group, 14 in red all pluripara group,and 26 in RSA group. Platelet-specific alloantibody was significantly associated with gravidity and the incidence of RSA (P<0.05) by chi-square analysis. Conclusion:Screening the expression of platelet-specific alloantibody during pregnancy can provide evidence for the diagnosis and treatment of RSA.
