Expression of Col9a1 Gene in Ankle Tissue of Rat Model of Idiopathic Congenital Talipes Equinovarus
10.16753/j.cnki.1008-2344.2016.06.003
- VernacularTitle:单纯性马蹄内翻足模型鼠足踝部组织中Col9a1基因表达的研究
- Author:
Zhengdong WANG
1
;
Xinyu WANG
;
Nan YAN
;
Xinyu MENG
;
Liang ZENG
;
Xiaojie WANG
Author Information
1. 沈阳医学院基础医学院解剖学教研室
- Keywords:
all-trans-retinoic acid;
Col9a1;
idiopathic congenital talipes equinovarus;
tissue;
collagen typeⅨ
- From:
Journal of Shenyang Medical College
2016;18(6):426-429
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the expression of Col9a1 gene in ankle tissue of rat model of idiopathic congenital talipes equinovarus (ICTEV) . Methods:ICTEV rat model was established. Immunofluorescence staining and immunohistochemical dyeing technology were used to detect the expression of Col9a1 protein in ankle tissue of model group and control group. Results:The expression level of Col9a1 protein in ankle tissue in model group was higher than that in the control group (P<0.05),Col9a1 gene expressed primarily in soft tissue and cartilage membrane. Conclusion:The increasing expression level of Col9a1 gene in ankle tissue of ICTEV rats may be related to clubfoot deformity.
