Effects of Luteolinl on the Proliferation and Differentiation in Human Periodontal Ligament Cells
10.16753/j.cnki.1008-2344.2016.05.006
- VernacularTitle:木犀草素对人牙周膜细胞增殖及成骨分化能力的影响
- Author:
Miao ZHANG
1
;
Xiuhua LIU
;
Hongyu ZHAO
Author Information
1. 新疆维吾尔自治区人民医院口腔科
- Keywords:
Luteolinl;
human periodontal ligament cell;
proliferation;
ALP;
RUNX2
- From:
Journal of Shenyang Medical College
2016;18(5):340-343
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the biological effects of Luteolinl on the proliferation and differentiation in human periodontal ligament cells (PDLC) . Methods:MTT, ALP kit and Q-PCR was used to detect the expression of osteogenesis related gene. Results:Luteolinl (100, 10, 1, 0.1, 0.01μmol/L) could increase the proliferation of PDLC, and there were significant differences compared with control group (P<0.05) . The ALP Kit results showed that Luteolinl could increase the ALP actiuty of PDLC (P<0.05) . The Q-PCR results showed that Luteolin could increase the expression of ALP and RUNX2 (P<0.05) . Conclution:At proper concentration,Luteolinl can increase the proliferation and differentiation of PDLC.