Diagnostic Value of ECT plus Serum ALP, Calcium Detection in Lung Cancer Patients with Bone Metastases
10.16753/j.cnki.1008-2344.2016.05.003
- VernacularTitle:ECT联合血ALP、血钙的检测对肺癌骨转移的诊断价值
- Author:
Ying GAO
1
;
Jiazheng XIE
Author Information
1. 皖南医学院弋矶山医院呼吸内科
- Keywords:
lung cancer;
bone metastasis;
ECT;
blood alkaline phosphatase;
calcium
- From:
Journal of Shenyang Medical College
2016;18(5):328-331
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To retrospectivey analyze of serum alkaline phosphatase (ALP), calcium levels in lung cancer patients undergoing bone scan (ECT) in order to evaluate their clinical values in diagnosis of bone metastases. Methods:The results of blood ALP, calcium (Ca2+) and ECT findings from 81 cases of lung cancer patients with bone metastases and 43 cases without bone metastases were collected,the levels of ALP,calcium were compared between the two groups. Lung cancer patients were performed a grading classification for the bone metastasis,serum ALP,calcium levels were analysed. The clinical values of serum ALP,calcium in monitoring bone metastasis were evaluated through receiver operating characteristic (ROC) curve. Results:(1) The serum levels of ALP,calcium in lung cancer patients with bone metastases were higher than those in patients without bone metastases (P<0.01) . (2) Grade Ⅲ patients had a significantly higher blood ALP level than grade Ⅰ, grade Ⅱ patients (P=0.003), whereas serum calcium levels were higher in gradeⅠpatients than that in gradeⅡ,Ⅲpatients,but there was no significant difference (P>0.05) . (3) The area under the curve (AUC) of blood ALP, calcium in lung cancer patients were 0.715, 0.769, respectively, when detection was combined, the sensitivity increased to 70.4%, and specificity remained at a high level. Conclusion:ECT combined with blood ALP, calcium has a diagnostic value in the detection of bone metastases in lung cancer patients, and can be used as a screening and monitoring methods.
