Research Progress of Raf Kinase Inhibitor Protein in Malignant Tumor
10.16753/j.cnki.1008-2344.2016.04.020
- VernacularTitle:Raf激酶抑制蛋白在恶性肿瘤中的研究进展
- Author:
Qin CAI
1
;
Jie WANG
Author Information
1. 沈阳医学院基础医学院
- Keywords:
Raf kinase inhibitor protein;
signaling pathway;
malignant tumor;
methylation
- From:
Journal of Shenyang Medical College
2016;18(4):284-286,290
- CountryChina
- Language:Chinese
-
Abstract:
Raf kinase inhibitor protein (RKIP) belongs to the family of phosphatidyle ethanolamine?binding protein, which plays an important role in the regulation of multiple signaling pathways in cells. Researches showed that RKIP was one of the malignant tumor suppressor factors,and its low expression was the important reason for the occurrence and development of malignant tumors,such as prostate cancer,lung cancer,breast cancer,colorectal cancer,acute myeloid leukemia,but the mechanism of RKIP low expression was still not very clear.Further research about RKIP not only can provide a new method for the diagnosis of malignant tumors,but also can provide a new way for the treatment of malignant tumors,also can provide a basis for predicting the recurrence and prognosis of malignant tumors.