Evaluation of the Correlation of Four System for Testing HIV-1 Genotype Drug Resistance

VernacularTitle:4种解释系统对HIV-1基因型耐药解释相关性评价
Author: Tianyi HE ¹ ; Qi GUAN
Author Information

1. 沈阳医学院附属中心医院检验科
Keywords: HIV-1; genotype resistant interpretation system; drug-resistant mutation
From: Journal of Shenyang Medical College 2016;18(4):237-241
CountryChina
Language:Chinese
Abstract: Objective:To compare the correlation of four drug-resistance interpretation system including HIVDB, ANRS, REGA and HIV GRADE for testing HIV-1 genotype drug resistance. Methods:Trendy subtypes and restructuring model of HIV-1 including B’,CRF01_AE and CRF07_BC were selected,each genotype was 200 series,600 samples were analyzed by four drug?resistance interpretation system, the results were divided into three levels including resistance (R), possible drug?resistance (I) and susceptible (S). Results:Four drug?resistance interpretation system had a high correlation in genotypic drug?resistance consequence (rs>0.57, P<0.01), CRF07_BC had the highest correlation, followed by subtype B, CRF01_AE was slightly lower.Conclusion:Four drug?resistance interpretation system has a high correlation in analyzing antiviral drug resistance for major epidemic of HIV in China.