Morphological Study for the Cell Invasiveness in Triple-negative Breast Cancer Cell Line MDA-MB-231 Induced by Leptin

VernacularTitle:瘦素诱导乳腺癌三阴细胞系MDA-MB-231侵袭的形态学观察
Author: Weiqiang ZHOU ¹
Author Information

1. 沈阳医学院基础医学院
Keywords: Leptin; breast cancer; MDA-MB-231; invasiveness
From: Journal of Shenyang Medical College 2016;18(4):234-236
CountryChina
Language:Chinese
Abstract: Objective:To study the influence of Leptin on cell invasiveness in triple-negative breast cancer cell line MDA-MB-231. Method:Cell scratching and Transwell invasion assay were used to observe the impact of Leptin on cell invasiveness. Results:Compared with the control group, Leptin could significantly enhance the MDA-MB-231 migration to the center of scratches. Transwell experiment found that, compared to control cells, the invasive ability of MDA-MB-231 cells significantly increased with Leptin induction. It was displayed for the increasing cells that had penetrated the basement membrane and spread well. Conclusion:Leptin can significantly induce the migration and invasiveness for the breast cancer MDA-MB-231 cells.