Effect of Squamous Cell Antigen and Cyclin E on Cervical Intraepithelial Neoplasia and Cervical Cancer
10.16753/j.cnki.1008-2344.2016.03.011
- VernacularTitle:鳞状细胞抗原和细胞周期素E对宫颈上皮内瘤变和宫颈癌的影响
- Author:
Haiyan WU
1
;
Yanhong LI
;
Xinning ZHANG
;
Yiqiong PENG
Author Information
1. 广州医科大学附属第六医院清远市人民医院
- Keywords:
squamous cell antigen;
Cyclin E;
cervical intraepithelial neoplasia;
cervical cancer
- From:
Journal of Shenyang Medical College
2016;18(3):160-162
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the level of squamous cell antigen (SCC?Ag) and cyclin E in cervical intraepithelial neoplasia ( CIN) and cervical cancer, and to explore the clinical significance. Methods: From Nov 2012 to Nov 2015, 308 patients with CIN or cervical cancer were chosen as research objects, and 170 patients with uterine leiomyoma or uterine gland muscle disease for hyster?ectomy and after pathological examination of the normalcases were chosen as control group. The SCC?Ag level, positive expression rate in blood, and positive expression of Cyclin E in cervical tissue for patients with different cervical lesions were compared. Results: The SCC?Aglevel , positive expression rate in blood, and positive expression of Cyclin E in cervical tissue for patients with cervical canc?er, CIN were higher that those in the control group ( P<0?05) . The SCC?Aglevel, positive expression rate in blood, and positive ex?pression of Cyclin E in different CIN grades and different stages of cervical cancer patient had significant difference ( P<0?05) . Con?clusion: Blood SCC?Ag level and positive expression, Cyclin E positive expression in the cervical tissue have a close relationship with occurrence and development of CIN and cervical cancer .
