Analysis of risk factors of early acute kidney injury after liver transplantation from DCD donor liver
10.3969/j.issn.1674-7445.2018.02.007
- VernacularTitle:DCD供肝肝移植术后早期急性肾损伤相关危险因素分析
- Author:
Wanli WANG
1
,
2
;
Qingshan LI
;
Ying ZHOU
;
Li WANG
;
Huanchen SHA
;
Min TIAN
;
Jianhua SHI
;
Jian DONG
;
Xuemin LIU
;
Xiaogang ZHANG
;
Chang LIU
;
Liang YU
;
Yi LYU
;
Bo WANG
Author Information
1. 710061 西安交通大学第一附属医院肝胆外科暨肝移植中心
2. 巴中市中心医院普外二科
- Keywords:
Liver transplantation;
Donation after cardiac death (DCD);
Acute kidney injury (AKI);
Risk factor;
Red blood cell;
Continuous renal replacement therapy;
Hemorrhage volume
- From:
Organ Transplantation
2018;9(2):130-136
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the risk factors of early acute kidney injury (AKI) after liver transplantation from donation after cardiac death(DCD) donor liver. Methods Clinical data of 184 donors and recipients undergoing liver transplantation from DCD donor liver were retrospectively analyzed. According to the incidence of early AKI, all participants were divided into the AKI and non-AKI groups. The patients in the AKI group were subject to AKI staging. Baseline data, preoperative, intraoperative and postoperative related parameters were statistically compared between two groups. The cumulative survival rate and clinical prognosis of patients in non-AKI group and AKI group with different staging were statistically analyzed by Kaplan-Meier curve analysis. Results Among 184 patients, 68 cases (37.0%) presented with early AKI after liver transplantation including 31 stage 1 AKI, 26 stage 2 AKI and 11 stage 3 AKI, mainly occurring within postoperative 3 d. Univariate analysis revealed that preoperative levels of albumin <35 g/L, preoperative levels of serum sodium ≤137 mmol/L, operation time>7.5 h, intraoperative hemorrhage volume>3 000 mL, intraoperative red cell infusion volume>15 U and intraoperative urine amount ≤100 mL/h were the risk factors of early AKI after liver transplantation (all P<0.05). Multi-variate Logistic regression analysis demonstrated that intraoperative red cell infusion >15 U was an independent risk factor of early AKI after liver transplantation [odds ratio(OR) 1.061, 95% confidence interval(CI)1.008-1.118,P=0.024].Result of Kaplan-Meier survival curve suggested that the cumulative survival rate was gradually reduced along with the aggravation of AKI with statistical significance (all P<0.05). Conclusions The incidence of early AKI following liver transplantation is relatively high. The severity of early AKI is intimately correlated with the short- and long-term prognosis of the recipients. A large quantity of intraoperative red blood cell infusion is an independent risk factor of AKI.
