Treatment of Henoch-Sch?nlein Purpura with Intravenous Immunoglobulin.
10.12701/yujm.2001.18.2.246
- Author:
Hyo Seok CHUNG
1
;
Won Duck KIM
;
Eun Sil LEE
;
Kwang Hae CHOI
;
Yong Hoon PARK
;
Yong Jin KIM
Author Information
1. Department of Pediatrics College of Medicine, Yeungnam University, Daegu, Korea.
- Publication Type:Original Article
- Keywords:
Henoch-Schonlein purpura;
Nephrotic syndrome;
Abdominal pain;
Intravenous immunoglobulin
- MeSH:
Abdominal Pain;
Antibodies;
Glomerulonephritis;
Hematuria;
Humans;
Immunization, Passive;
Immunoglobulin A;
Immunoglobulins*;
Kidney;
Mesangial Cells;
Methylprednisolone;
Nephrotic Syndrome;
Proteinuria;
Purpura*;
Purpura, Schoenlein-Henoch
- From:Yeungnam University Journal of Medicine
2001;18(2):246-252
- CountryRepublic of Korea
- Language:English
-
Abstract:
We report the result of a high-dose intravenous immunoglobulin therapy in a Henoch-Sch?nlein purpura patient with severe abdominal pain and nephrotic syndrom who did not respond to methylprednisolone pulse therapy. Kidney bbiopsy showed diffuse mesangial cell proliferative glomerulonephritis with fibrocellular crescent formation in approximately 50% of glomeruli. Mesangium of all glomeruli were strong positive for IgA and C3 antibodies. High-dose intravenous immunoglobulin treatment was introduced and dramatic improvement of gastrointestinal symptom and proteinuria as well as hematuria was noted. Immunoglobulin administration should be considered in Henoch-Schnlein purpura patients with sterois-resistant intractable dastrointestinal manifestation and renal involvenment.
