Clinical observation on the removal of donor specific antibody by double filtration plasmapheresis in renal transplant recipients
10.3969/j.issn.1674-7445.2017.06.009
- VernacularTitle:双重膜滤过式血浆置换清除肾移植受者供体特异性抗体的临床观察
- Author:
Qi LIAO
1
;
Qiuyan JIANG
;
Yan XIONG
;
Fengying WANG
;
Qiang YAN
;
Guimian ZOU
;
Weiguo SUI
Author Information
1. 解放军第 181 医院肾脏科 全军器官移植与透析治疗中心 广西代谢性疾病研究重点实验室
- Keywords:
Double filtration plasmapheresis;
Renal transplantation;
Donor specific antibody (DSA);
Recipient,highly sensitized;
Antibody-mediated rejection;
Luminex technology;
Human leukocyte antigen (HLA) antibody;
Albumin
- From:
Organ Transplantation
2017;8(6):455-459
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of double filtration plasmapheresis (DFPP) upon the removal of donor specific antibody (DSA) in highly sensitized recipients with renal transplantation. Methods Four highly sensitized recipients undergoing renal transplantation received 7 cycles of DFPP. Luminex technology was adopted to monitor the changes of DSA. Clinical efficacy, incidence of acute rejection and adverse reactions were observed. Results After DFPP, the DSA MFI [1036 (0-4113)] was significantly declined than that before treatment [6446 (2999-12905), Z= -2.503, P=0.012]. No hyperacute rejections occurred in four highly sensitized recipients undergoing renal transplantation.Acute rejection was noted in one case, which was mitigated by postoperative DFPP and adjustment of immunosuppressive agents. During postoperative follow-up, the function of transplant kidney was normal and no rejection reactions occurred. The level of albumin was decreased after DFPP. Conclusions DFPP can effectively remove the DSA in the recipients.It is an efficacious and safe approach to prevent the incidence of acute rejections in highly sensitized recipients after renal transplantation.
