Comparison of clinical efficacy between ABO-incompatible and ABO-compatible liver transplantation in children: a Meta-analysis
10.3969/j.issn.1674-7445.2017.06.002
- VernacularTitle:儿童ABO血型不合与相合肝移植疗效比较的Meta分析
- Author:
Wei TIAN
1
,
2
;
Wentao LI
;
Shikai ZHU
;
Hongji YANG
Author Information
1. 646000 四川泸州,西南医科大学临床医学院
2. 四川省医学科学院 四川省人民医院器官移植中心
- Keywords:
Liver transplantation;
children;
ABO-incompatible;
ABO-compatible;
Meta analysis;
Survival rate of recipient;
Survival rate of graft;
Rejection reaction;
Biliary tract complication
- From:
Organ Transplantation
2017;8(6):417-423
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the clinical efficacy between pediatric ABO-incompatible liver transplantation (ILT) and ABO-compatible liver transplantation (CLT) by Meta-analysis. Methods Relevant studies published until May 2017 were electronically retrieved from PubMed, Embase, Cochrane library, China national knowledge internet (CNKI),Wanfang and VIP databases. According to the inclusion and exclusion criteria, the publications eligible were screened and clinical data were extracted. Meta-analysis was performed using the random or fixed effect model analyses with Review Manager 5.3 statistical software. Results Eleven retrospective cohort studies in English were selected. Meta-analysis demonstrated that the postoperative 1-year survival rate of the recipients in the ILT group was significantly lower than that in the CLT group [odds ratio (OR)=0.64, 95% confidence interval (CI) 0.49-0.83, P=0.0007)]. In the ILT group, the incidence of postoperative rejection reactions was considerably higher compared with that in the CLT group (OR=1.96,95% CI 1.03-3.72, P=0.04). No statistical significance was observed in the postoperative 3- and 10-year survival rate of the recipients, 1-, 3- and 10-year survival rate of the graft and the incidence of postoperative biliary tract complications between two groups (all P>0.05). Conclusions Compared with their CLT counterparts, the 1-year survival rate of the ILT recipients is lower, whereas the incidence of rejection reactions is higher. However, the long-term survival rate of both the recipient and graft and the incidence of biliary tract complications do not significantly differ between CLT and ILT. ILT is a relatively ideal option for emergent patients or those lacking of liver graft with compatible blood group for a long period of time.
