Effect of hypothermia status in donors on renal graft function after renal transplantation from donation after citizen's death
10.3969/j.issn.1674-7445.2017.05.008
- VernacularTitle:供体亚低温状态对公民逝世后器官捐献移植肾功能的影响
- Author:
Kepu LIU
1
;
Geng ZHANG
;
Zhibin LI
;
Dongli RUAN
;
Long GAO
;
Huilong WANG
;
Wenfeng ZHENG
;
Jianlin YUAN
Author Information
1. 第四军医大学西京医院泌尿外科
- Keywords:
Donation after citizen's death;
Renal transplantation;
Hypothermia;
Normal temperature;
Delayed graft function;
Therapeutic hypothermia;
Primary nonfunction;
Urine volume;
Warm ischemia time;
Cold ischemia time
- From:
Organ Transplantation
2017;8(5):376-380
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of hypothermia status in the donors upon the renal graft function after renal transplantation from donation after citizen's death. Methods Thirty-six eligible donors were randomly divided into the normal temperature (body temperature 36.5-37.5 ℃ , n=19) and hypothermia groups (body temperature 34.0-35.0 ℃ , n=17). The matched recipients undergoing renal transplantation were also assigned into the normal temperature (n=38) and hypothermia groups (n=34). Perioperative conditions of the donors and recipients were compared between two groups. And postoperative renal graft function of the recipients were statistically compared between two groups, including the incidence of delayed graft function (DGF) and primary nonfunction (PNF). Results No statistical significance was identified in the perioperative amount of urine volume, serum creatinine (Scr), systolic blood pressure, saturation oxygen, warm ischemia time and cold ischemia time of the donors between two groups (all P>0.05). No statistical significance was noted in terms of the operation time, intraoperative mean blood glucose and intraoperative mean arterial pressure of the recipients between two groups (all P>0.05). Postoperative incidence of DGF of the recipients in the hypothermia group was 6%, significantly lower than that in the normal temperature group (24%) (χ2=4.393, P=0.036). Postoperative incidence of PNF of the recipients was 3% in both the hypothermia and normal temperature groups with no statistical significance (χ2=0.000, P=1). Conclusions The hypothermia status of the donors can significantly reduce the incidence of DGF, whereas exerts no evident effect upon the incidence of PNF in the recipients.
