Successful pregnancy and delivery in a patient with Niemaoh-Pick disease after liver transplantation: report of one case and literature review
10.3969/j.issn.1674-7445.2017.04.010
- VernacularTitle:尼曼匹克病肝移植术后成功妊娠分娩1例并文献复习
- Author:
Qingchun HAO
1
;
Qiang ZENG
;
Baowang LIU
;
Liang TENG
;
Jian DOU
Author Information
1. 河北医科大学第三医院肝胆外科
- Keywords:
Niemaoh-Pick disease,type B;
Liver transplantation;
Pregnancy;
Tacrolimus;
Serum drug concentration;
Breastfeed;
Teratogenesis
- From:
Organ Transplantation
2017;8(4):304-307
- CountryChina
- Language:Chinese
-
Abstract:
Objective To summarize the clinical experience of patient diagnosed with Niemaoh-Pick disease being pregnant after liver transplantation. Methods Clinical data of one case of type B Niemaoh-Pick disease being pregnant after liver transplantation were retrospectively analyzed. Results The patient successfully underwent liver transplantation combined with splenic artery ligation on July 8, 2011. She was well recovered postoperatively. After surgery, she received conventional anti-rejection treatment, and gradually switched to use of tacrolimus at a dosage of 2.5 mg/d. The serum drug concentration was maintained at 2 ng/mL. In September 2015, she was successfully pregnant. On June 2, 2016, she delivered a male infant through cesarean section. She could breastfeed the infant in a low quantity early after delivery. Both the mother and infant were followed up until submission date. The mother was physically stable and the infant grew normally. Conclusions Patients diagnosed with Niemaoh-Pick disease can obtain favorable clinical outcomes of pregnancy and delivery after liver transplantation.
