Changes of erythrocytes surface molecule CD35,CD58 and CD59 expression in recipients infected with cytomegalovirus after renal transplantation
10.3969/j.issn.1674-7445.2016.06.012
- VernacularTitle:巨细胞病毒感染肾移植受者红细胞表面分子CD35、CD58、CD59表达的变化
- Author:
Xiangrui KONG
1
;
Li XIAO
;
Wen CHEN
;
Wenmei FAN
;
Jian BAI
;
Yu GAO
;
Xihui MA
;
Lili BI
;
Bingyi SHI
Author Information
1. 解放军第309医院全军器官移植研究室 北京市器官移植与免疫调节重点实验室
- Keywords:
Renal transplantation;
Cytomegalovirus;
Active infection;
Erythrocytes;
CD35;
CD58;
CD59
- From:
Organ Transplantation
2016;7(6):473-489
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the change rules and its significance of erythrocytes surface molecule CD35 , CD58 and CD59 expression in recipients infected with cytomegalovirus (CMV)after renal transplantation. Methods Eighty-two recipients undergoing allogeneic renal transplantation were selected and divided into the negative (n=21 )and positive CMV groups (n=61 )based on the qualitative detection of CMV-pp65 antigen in peripheral blood. According to the results of CMV-pp65 (+)leucocyte count,all 61 patients in positive CMV group were further divided into low (n=55)and high active infection subgroups (n =6 ). Healthy adults were recruited into the normal control group (n =30 ). The expression levels of CMV-pp65 antigen,erythrocytes surface molecule CD35,CD58 and CD59 were measured by flow cytometry. Results Compared with normal control group,the expression levels of erythrocytes surface molecule CD35 , CD58 and CD59 in the positive CMV group were significantly down-regulated,and the CD35 and CD59 expression in the negative CMV group were considerably down-regulated (all P<0. 05 ). Compared with negative CMV group,the expression levels of CD58 and CD59 in the positive CMV group were significantly down-regulated (both P<0. 05 ). The expression levels of CD35 and CD59 in the high active infection subgroup were significantly lower than those in the low active infection subgroup (both P<0. 05 ). Conclusions The more severe active CMV infection after renal transplantation,the lower expression of erythrocytes surface molecule CD35,CD58 and CD59,hinting that red cell immune dysfunction is probably involved with active CMV infection.
