Correlation of tumor recurrence after liver transplantation for hepatocellular carcinoma with the expression ;levels of regulatory T cells and cytokines in peripheral blood
10.3969/j.issn.1674-7445.2016.05.010
- VernacularTitle:肝癌肝移植术后肿瘤复发与外周血调节性T细胞及细胞因子表达水平的关系
- Author:
Shaozhen YANG
1
;
Lin ZHOU
;
Guosheng DU
;
Jiyong SONG
;
Zhidong ZHU
;
Likui FENG
;
Longlong SUO
;
Yonggen ZHENG
Author Information
1. 河北北方学院
- Keywords:
Liver transplantation;
Tumor recurrence;
Sirolimus;
Regulatory T cell;
Cytokine
- From:
Organ Transplantation
2016;7(5):382-385
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the correlation of tumor recurrence after liver transplantation for hepatocellular carcinoma (HCC)with the expression levels of regulatory T cell (Treg)and cytokines in peripheral blood. Methods A total of 56 patients who underwent liver transplantation in the 309th Hospital of People's Liberation Army from 2010 to 2014 were studied. According to the postoperative pathological data,all the patients were divided into the group of liver transplantation for HCC (HCC group,n=28)and group of liver transplantation for cirrhosis (liver cirrhosis group,n=28), of which the HCC group was further divided into non-recurrence group (n=8)and recurrence group (n=20)according to the situation of postoperative tumor recurrence. The expression levels of Treg and cytokines [vascular endothelial growth factor (VEGF),interleukin (IL)-2,IL-10,IL-12,transformation growth factor (TGF)-βand interferon (IFN)-γ]in peripheral blood of the patients in various groups were compared. Results Compared with the liver cirrhosis group,levels of IFN-γand IL-12 in the non-recurrence group increased significantly (both P<0.05);levels of Treg%,VEGF,IFN-γ, IL-10 and TGF-βin the recurrence group increased significantly,while levels of IL-2 and IL-12 decreased significantly (all P<0.05). Compared with the non-recurrence group,levels of Treg%,VEGF,IL-10 and TGF-βin the recurrence group increased significantly,while levels of IFN-γ,IL-2 and IL-12 decreased significantly (all P<0.05 ). Conclusions Levels of Treg and cytokines can be used to predict the tumor recurrence after liver transplantation for HCC.
